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Sports drinks like Gatorade and PowerAde replenish lost electrolytes, but contain large amounts of sugar and calories. Glucuronidation is catalyzed by uridine diphosphoglucuronosyltransferases (UGTs), which are membrane-bound enzymes of the endoplasmic reticulum. By the 1950s, competitive athletes were receiving such drugs, and other individuals as well. Androgens and anabolic steroids are considered not medically necessary to increase muscle strength or muscle size to enhance performance. Their reasoning is that most of the calories burned during HIIT come from stored muscle glycogen (carbs) rather than coming from stored adipose tissue.
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George Mitchell, released in December, mentioned dozens of baseball players as having used steroids and described their use as "widespread.
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